OncodriveFML

Distinguishing the driver mutations from somatic mutations in a tumor genome is one of the major challenges of cancer research. This challenge is more acute and far from solved for non-coding mutations. OncodriveFML is a method designed to analyze the pattern of somatic mutations across tumors in both coding and non-coding genomic regions to identify signals of positive selection, and therefore, their involvement in tumorigenesis. We described the method and illustrated its usefulness to identify protein coding genes, promoters, untranslated regions, intronic splice regions, and lncRNAs-containing driver mutations in several malignancies in Mularoni et al., Genome Biology 2016.

To use OncodriveFML check its website or download the source code from our git repository.

OncodriveFML is a project developed by the Barcelona Biomedical Genomics Lab.

We are a research group integrated in the Institute for Research Biomedicine in Barcelona, which is part of the Barcelona Institute of Science and Technology. Our lab is located at the Barcelona Science Park.

Our main research interest is the computational study of cancer at the genomic level.


Check the README file to find infomation about licensing and installation.

Run the example for a quick check of the installation.